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The flick will be directed by Wes Anderson ("The Royal Tenenbaums").
The Disney project, due to start shooting this month in Rome, follows the experiences of an oceanographer and his crew on a series of wild deep-sea adventures, including the search for a shark.
Dafoe will star as the ship's engineer and the surrogate brother of Murray's character, while Blanchett will play the female lead, a member of the ship's crew.
Jeff Goldblum, Peter Stormare, Wallace Wolodarsky and Bud Cort round out the cast. Murray, Huston and Wilson previously starred in "The Royal Tenenbaums," a hit release in 2001.
Dafoe, who has a role in Robert Rodriguez ' upcoming "Once Upon a Time in Mexico," is currently in Bulgaria filming "Control" opposite Ray Liotta. Other upcoming films include Martin Scorsese 's "The Aviator," which also stars Blanchett.
The Australian actress next stars in the Toronto International Film Festival selection "Veronica Guerin," followed by Ron Howard 's Western "The Missing".
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